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Immediate constraint-induced movement therapy causes local hyperthermia that exacerbates cerebral cortical injury in rats.

Immediate constraint-induced movement therapy causes local hyperthermia that exacerbates cerebral cortical injury in rats.

Authors :
DeBow, Suzanne B.
McKenna, John E.
Kolb, Bryan
Colbourne, Frederick
Source :
Canadian Journal of Physiology & Pharmacology. Apr2004, Vol. 82 Issue 4, p231-237. 7p. 1 Black and White Photograph, 1 Graph.
Publication Year :
2004

Abstract

Constraint-induced movement therapy (CIMT), which involves restraint of the nonimpaired arm coupled with physiotherapy for the impaired arm, lessens impairment and disability in stroke patients. Surprisingly, immediate ipsilateral forelimb immobilization exacerbates brain injury in rats. We tested whether immediate ipsilateral restraint for 7 days aggravates injury after a devascularization lesion in rats. Furthermore, we hypothesized that ipsilateral restraint aggravates injury by causing hyperthermia. In experiment 1, each rat received two lesions, one in the motor cortex and one in the visual cortex. Ipsilateral restraint increased only the motor cortex lesion. In additional rats, no differences in core temperature occurred after ipsilateral or contralateral restraint. Thus, ipsilateral restraint does not aggravate injury by a systemic side effect. In experiment 2, we hypothesized that ipsilateral restraint causes hyperthermia in the region surrounding the initial cortical lesion. Brain temperature, measured via telemetry, was significantly higher (~1 °C for 24 h) with ipsilateral restraint. A third experiment similarly found that ipsilateral restraint aggravates injury and causes local cortical hyperthermia and that contralateral restraint with externally induced mild hyperthermia aggravates injury. In conclusion, immediate ipsilateral restraint aggravates injury apparently by localized events that include hyperthermia. Caution must be exercised in applying early CIMT to humans, as hyperthermia is detrimental. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00084212
Volume :
82
Issue :
4
Database :
Academic Search Index
Journal :
Canadian Journal of Physiology & Pharmacology
Publication Type :
Academic Journal
Accession number :
13597974
Full Text :
https://doi.org/10.1139/Y04-013