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Facile Development of Superparamagnetic Nanoparticle Encapsulated Protein based Nanocarrier for Targeted Drug Delivery Application.
- Source :
-
AIP Conference Proceedings . 2019, Vol. 2100 Issue 1, p020068-1-020068-4. 4p. - Publication Year :
- 2019
-
Abstract
- In this work, facile development of superparamagnetic Fe3O4 nanoparticle encapsulated bovine serum albumin (BSA) based nanocarrier (Fe3O4@BSA) for targeted drug delivery application has been reported. First, highly monodisperse and well crystalline superparamagnetic Fe3O4 nanoparticle was prepared and then a green and simple sonochemical method was used for the development of Fe3O4@BSA nanocarrier. The structural, morphological, and magnetic properties of the prepared Fe3O4@BSA nanocarrier have been studied by XRD, TEM, SAED, FTIR and VSM techniques. The particle sizes of Fe3O4 nanoparticle and Fe3O4@BSA nanocarrier were found to be 5-10 nm and 50-300 nm respectively. TEM micrographs and FTIR analysis confirmed the successful coating of amorphous BSA on crystalline Fe3O4 NPs. Magnetic measurement revealed the superparamagnetic nature of the prepared Fe3O4@BSA nanocarrier. Fe3O4@BSA nanocarrier with smaller particle sizes, good physical and chemical stability, excellent water dispersability and low toxicity could have potential for targeted drug delivery applications. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0094243X
- Volume :
- 2100
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- AIP Conference Proceedings
- Publication Type :
- Conference
- Accession number :
- 136120162
- Full Text :
- https://doi.org/10.1063/1.5098622