Facile Development of Superparamagnetic Nanoparticle Encapsulated Protein based Nanocarrier for Targeted Drug Delivery Application.

In this work, facile development of superparamagnetic Fe3O4 nanoparticle encapsulated bovine serum albumin (BSA) based nanocarrier (Fe3O4@BSA) for targeted drug delivery application has been reported. First, highly monodisperse and well crystalline superparamagnetic Fe3O4 nanoparticle was prepared and then a green and simple sonochemical method was used for the development of Fe3O4@BSA nanocarrier. The structural, morphological, and magnetic properties of the prepared Fe3O4@BSA nanocarrier have been studied by XRD, TEM, SAED, FTIR and VSM techniques. The particle sizes of Fe3O4 nanoparticle and Fe3O4@BSA nanocarrier were found to be 5-10 nm and 50-300 nm respectively. TEM micrographs and FTIR analysis confirmed the successful coating of amorphous BSA on crystalline Fe3O4 NPs. Magnetic measurement revealed the superparamagnetic nature of the prepared Fe3O4@BSA nanocarrier. Fe3O4@BSA nanocarrier with smaller particle sizes, good physical and chemical stability, excellent water dispersability and low toxicity could have potential for targeted drug delivery applications. [ABSTRACT FROM AUTHOR]