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TRPA1 is selected as a semi-conserved channel during vertebrate evolution due to its involvement in spermatogenesis.

TRPA1 is selected as a semi-conserved channel during vertebrate evolution due to its involvement in spermatogenesis.

Authors :
Saha, Somdatta
Sucharita, Samikshya
Majhi, Rakesh Kumar
Tiwari, Ankit
Ghosh, Arijit
Pradhan, Sunil Kumar
Patra, Bijay Kumar
Dash, Rashmi Ranjan
Nayak, Rabi Narayan
Giri, Sunil C.
Routray, Padmanav
Kumar, Abhishek
Kumar G, Pradeep
Goswami, Chandan
Source :
Biochemical & Biophysical Research Communications. Apr2019, Vol. 512 Issue 2, p295-302. 8p.
Publication Year :
2019

Abstract

TRPA1 is a non-selective cation channel originated in invertebrates. The genomic locus containing TRPA1 gene remains highly conserved and retained in all vertebrates. TRPA1 gene is evolutionarily selected, yet maintained as a highly diverged protein. Throughout the vertebrate evolution, the extracellular loops of TRPA1 become most diverged indicating that TRPA1 may be involved in detecting large spectrum and uncertain stimulus which is critical for adaptive benefit. We tested the expression of TRPA1 in mature sperm from different vertebrates. This is the first report demonstrating that TRPA1 is expressed endogenously in mature spermatozoa of multiple species representing entire vertebrate phyla. However, its specific localization within sperm remains species-specific. Accordingly, we report that in rodents TRPA1 expression correlates with different stages of spermatogenesis. We propose that presence of endogenous TRPA1 in testes and in mature sperm provides reproductive benefit. • The genomic locus containing TRPA1 gene remains highly conserved and retained in all vertebrates. • TRPA1 gene is evolutionarily selected, yet maintained as a highly diverged protein including divergent extracellular loops. • TRPA1 is expressed endogenously in mature spermatozoa from different vertebrates. • TRPA1 expression correlates with different stages of spermatogenesis. • Presence of endogenous TRPA1 in testes and in mature sperm may provide reproductive benefit. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
0006291X
Volume :
512
Issue :
2
Database :
Academic Search Index
Journal :
Biochemical & Biophysical Research Communications
Publication Type :
Academic Journal
Accession number :
136133121
Full Text :
https://doi.org/10.1016/j.bbrc.2019.02.121