Fluorescent 10B embedded nanodiamonds as 10B delivery agent for boron neutron capture therapy.

Boron neutron capture therapy is a potentially powerful anti-cancer treatment, the success of which depends heavily on the boron delivery agent. Enabling the real-time tracing of delivery agents as they move through the body is crucial to the further development of boron neutron capture therapy. In this study, we fabricate fluorescent 10B embedded nanodiamonds using physical ion implantation in conjunction with a two-step annealing process. Fluorescent 10B embedded nanodiamonds perform well in cell viability test. The red fluorescence of the 10B embedded nanodiamonds allows their use in fluorescence microscopy and in vivo imaging systems, thereby making it possible to conduct tracking in real time. The proposed fluorescent 10B embedded nanodiamonds, combining optical visibility and 10B transport capability, might be a promising boron delivery agent suitable for a wide range of biomedical applications. [ABSTRACT FROM AUTHOR]