熊去氧胆酸联用思美泰对妊娠期肝内胆汁淤积症重症患者瘙痒程度、妊娠结局及肝功能的影响

Objective: To investigate the effects of ursodeoxycholic acid combined with transmetil on the itching degree,pregnancy outcome and liver function in patients with severe intrahepatic cholestasis of pregnancy(ICP). Methods: 76 patients with severe ICP who were treated in our hospital from June 2016 to December 2017 were enrolled. The patients were divided into study group(n=38)and control group(n=38)according to the random number table method. The control group was treated with ursodeoxycholic acid, and the study group was treated with ursodeoxycholic acid combined with transmetil. The levels of Ribaha skin itching degree score, aspartate aminotransferase(AST), alanine aminotransferase(ALT), total bile acid(TBA), serum total bilirubin(TB) before treatment and 7 days after treatment were compared between the two groups. The pregnancy outcomes of the two groups were compared.Results: 7 days after treatment, the itching degree scores of the two groups were significantly lower, and the study group was lower than that of the control group(P<0.05). 7 days after treatment, the levels of AST, ALT, TBA and TB in the two groups were significantly lower, and the levels of AST, ALT, TBA and TB in the study group were lower than those in the control group, the difference was statistically significant(P<0.05). There was no significant difference between the two groups in the incidence of neonatal asphyxia and neonatal body mass(P>0.05). The incidence of premature labor, fetal distress and meconium stained amniotic fluid in the study group were lower than those in the control group, and the difference was statistically significant(P<0.05). Conclusion: The ursodeoxycholic acid combined with transmetil can effectively relieve itching degree in patients with severe ICP, and it can improve liver function and pregnancy outcomes, the clinical effect is significant, it has positive clinical significance. [ABSTRACT FROM AUTHOR]