Back to Search
Start Over
The gut microbiota of hand, foot and mouth disease patients demonstrates down-regulated butyrate-producing bacteria and up-regulated inflammation-inducing bacteria.
- Source :
-
Acta Paediatrica . Jun2019, Vol. 108 Issue 6, p1133-1139. 7p. - Publication Year :
- 2019
-
Abstract
- <bold>Aim: </bold>This study explored the gut microbiota of children with hand, foot and mouth disease (HFMD).<bold>Methods: </bold>We enrolled 15 cases with HFMD admitted to the West China Second Hospital, Sichuan University, China, from July to September 2016 at a median age of three years. The controls were 15 healthy children of a similar age who underwent routine health examinations at the hospital during the same period. Gut microbiota was analysed using high throughput 16S ribosomal deoxyribonucleic acid sequencing.<bold>Results: </bold>The gut microbiota in the HFMD patients was distinct from the controls. Compared with the controls, the composition of gut microbiota in the HFMD cases represented a reduction of two butyrate-producing bacteria, Ruminococcus (0.73 ± 1.28 versus 7.78 ± 20.01, p = 0.026) and Roseburia (0.67 ± 1.69 versus 1.61 ± 3.27, p = 0.024) and an up-regulation of Escherichia (5.26 ± 10.50 versus 1.59 ± 5.90,p < 0.01) and Enterococcus (4.12 ± 12.49 versus 0.12 ± 0.41, p = 0.015).<bold>Conclusion: </bold>The dysbiosis of gut microbiota of the HFMD cases included a reduction of butyrate-producing bacteria and an up-regulation of inflammation-inducing bacteria. These may have impaired the intestinal biological mucosal barrier and host immune functions, promoting the invasion of the enterovirus. [ABSTRACT FROM AUTHOR]
- Subjects :
- *FOOT & mouth disease
*ENTEROCOCCUS
*DNA
*BACTERIA
*PERIODIC health examinations
Subjects
Details
- Language :
- English
- ISSN :
- 08035253
- Volume :
- 108
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Acta Paediatrica
- Publication Type :
- Academic Journal
- Accession number :
- 136420532
- Full Text :
- https://doi.org/10.1111/apa.14644