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Asymmetric Lewis Acid Catalyzed Electrochemical Alkylation.
- Source :
-
Angewandte Chemie International Edition . 5/20/2019, Vol. 58 Issue 21, p6999-7003. 5p. - Publication Year :
- 2019
-
Abstract
- Lewis‐acid catalysis and electrochemistry represent two powerful fields that have found widespread application in organic chemistry. Reported herein is an asymmetric electrosynthesis in combination with a chiral Ni catalyst leading to an intermolecular alkylation reaction in good yields with excellent enantioselectivities (up to 97 % ee). Mechanistic studies suggest that the Lewis‐acid‐bound radical intermediate from a single‐electron anodic oxidation selectively reacts with the benzylic radical species to generate the desired adducts. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14337851
- Volume :
- 58
- Issue :
- 21
- Database :
- Academic Search Index
- Journal :
- Angewandte Chemie International Edition
- Publication Type :
- Academic Journal
- Accession number :
- 136420627
- Full Text :
- https://doi.org/10.1002/anie.201901801