Three novel mutations of the ATP2A2 gene in Chinese patients with Darier disease.

The article presents a study on the mutations of the ATP2A2 gene in Chinese patients with Darier disease. Topics discussed include information on the Darier disease as a rare autosomal dominant genodermatosis with almost complete penetrance, characterized by abnormal keratinization and acantholysis; discussions on the clinical manifestations include multiple dark-brown keratotic plaques and warty papules covered by thick crusts particularly in seborrheic areas.