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PIVKA-II level is correlated to development of portal vein tumor thrombus in patients with HBV-related hepatocellular carcinoma.
- Source :
-
Infectious Agents & Cancer . 5/14/2019, Vol. 14 Issue 1, pN.PAG-N.PAG. 1p. 2 Charts, 3 Graphs. - Publication Year :
- 2019
-
Abstract
- Aim: To evaluate the correlation of serum PIVKA-II levels and development of portal vein tumor thrombus (PVTT) in hepatocellular carcinoma (HCC) patients. Methods: One hundred and twenty-three patients with newly diagnosed HCC were included in this study between March 2016 and October 2018. Thirty-five of these patients were detected with PVTT and all subjects were randomly divided to analysis group (N = 73) and validation (N = 50) group. Serum levels of PIVKA-II, laboratory tests including serum aspartate aminotransferase, total bilirubin, platelet count, albumin levels were demonstrated in all the patients. T-test, chi-squared test and logistic regression was used for analyzing data. Diagnostic efficiency and cut-off value of PIVKA-II in PVTT development of HCC patients were calculated using receiver operator curve (ROC) analysis. Results: Serum level of PIVKA-II in HCC patients with PVTT was significantly higher than that in HCC patients without PVTT (995.8 mAU/ml vs 94.87 mAU/ml; P = 0.003), as well as D-dimer levels (2.12 mg/L vs 0.56 mg/L P = 0.001). Univariate analysis showed that high serum D-dimer level was an independent risk factor for development of PVTT (OR = 1.22, 95%CI 1.02–1.45). ROC curve showed that among analysis group, the area under ROC curve (AUROC) of PIVKA-II was 0.73 (95%CI 0.59–0.86). For the detection of PVTT in HCC, PIVKA-II had a sensitivity of 83.7% and a specificity of 69.2% at a cutoff of 221.26 mAU/ml, which had a sensitivity of 85.71% and a specificity of 55.56% in validation group, respectively. Conclusion: Serum PIVKA-II level is a potential marker for diagnosis of PVTT in HCC patients, which may guide therapeutic strategy and assessment of tumor prognosis of HCC. [ABSTRACT FROM AUTHOR]
- Subjects :
- *VENOUS thrombosis diagnosis
*VENOUS thrombosis risk factors
*ASPARTATE aminotransferase
*BILIRUBIN
*BIOMARKERS
*CHI-squared test
*HEPATITIS B
*PORTAL vein
*HEPATOCELLULAR carcinoma
*PROTEIN precursors
*PROTHROMBIN
*STATISTICAL sampling
*STATISTICS
*T-test (Statistics)
*LOGISTIC regression analysis
*ALBUMINS
*RECEIVER operating characteristic curves
*FIBRIN fibrinogen degradation products
*PLATELET count
*DISEASE complications
*PROGNOSIS
*DIAGNOSIS
Subjects
Details
- Language :
- English
- ISSN :
- 17509378
- Volume :
- 14
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Infectious Agents & Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 136441423
- Full Text :
- https://doi.org/10.1186/s13027-019-0229-6