Fe-Catalyzed Bisphosphorylation of Amino-2-en-1-ones with Trialkyl Phosphites.

A facile bisphosphorylation of amino-2-en-1-ones with trialkyl phosphites mediated by iron is developed. The reaction is considered to go through two Michael addition progresses. A variety of amino-2-en-1-ones are bisphosphorylated in high yields with functional group tolerance. In addition, the protocol of introduction of two different phosphates into one molecule is successful through a cascade reaction. [ABSTRACT FROM AUTHOR]