NEUROLEPTICKÝ MALIGNÍ SYNDROM (PŘEHLEDOVÝ ČLÁNEK A KAZUISTIKY).

Neuroleptic malignant syndrome (NMS) is an antipsychotic-induced, life-threatening condition, characterized by hyperpyrexia, muscle rigidity, qualitative alteration of consciousness and autonomic nervous system dysregulation. Neuroleptic malignant syndrome was described early after introduction of antipsychotics into clinical practice. According the recent review the reported incidence of NMS was 0.02% to 0.03%, with a mortality rate of 5.6%. With the second-generation antipsychotics more frequently an atypical clinical picture, characterized by lower frequency and lower intensity of basal symptoms is found. The treatment includes supportive treatment and specific drug therapy. Case reports bring attention to risk factor for development of NMS. [ABSTRACT FROM AUTHOR]