Nano-facilitated drug delivery strategies in the treatment of plasmodium infection.

• Malaria, a protozoal infection caused by Plasmodium parasites leading to more than one million deaths each year. • The malaria parasites turn to acquire resistance against most of the existing drugs. • The intracellular nature and scattered location of the parasites produce a great challenge for developing a new molecule. • Nanotechnology based malaria therapy could be one of the approaches to target a drug directly into the infected host cells. Malaria, one of the major infectious disease-causing sizeable morbidity, mortality and economic loss worldwide. The main drawback for the failure to eradicate malaria is the spread of multiple drug resistance to the majority of currently available chemotherapy. At present nanotechnology offers an advanced opportunity in the delivery of drugs and vaccines to the desired targeted site in the body following oral and systemic administration. It confers the major advantages like improving drug pharmacokinetic profiles, reduce dose frequency and reduction in drug toxicity. Hence, Nano-based drug delivery system can provide a promising prospect in the way of malaria treatment. This paper is a review of recent researches highlighting includes nanocarriers loaded antimalarial drugs for better therapeutic efficacy and future perspective in the treatment of malaria. [ABSTRACT FROM AUTHOR]