Influence of forkhead box protein 3 polymorphisms (rs2232365, rs3761548) with the outcome of pregnancy: A meta‐analysis.

Dysfunction of regulatory T cells (Tregs) may contribute to certain immune‐related pregnancy complications. Forkhead box protein 3 (FOXP3) is the key transcription factor of Treg. We performed a systematic review and meta‐analysis to evaluate the possible association between FOXP3 polymorphisms −924A/G (rs2232365) and −3279C/A (rs3761548) and immune‐related pregnancy complications. After reviewing 78 fully published studies, 10 studies fulfilled previously defined eligibility criteria and were used for meta‐analysis. Two single nucleotide polymorphisms showed a significant correlation with increased or reduced risk for immune‐related pregnancy complications. For rs3761548, women with allele A were significantly at a higher risk than women carrying allele C (odds ratio = 1.29, 95% confidence interval: 1.20–1.38; p = 0.001). For rs2232365, women with GG or AG genotype were at a higher risk than women with genotype AA, thereby, allele G was significantly associated with a higher risk than allele A. Our meta‐analysis supports the notion that immune‐related pregnancy complications might be linked to genetic variations in the FOXP3 gene. [ABSTRACT FROM AUTHOR]