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A multicomponent two-step strategy for the synthesis of polysubstituted pyrrolo[3,2-c]pyridin-4-ones using a solid acid as a recyclable catalyst.
- Source :
-
Green Chemistry . 6/7/2019, Vol. 21 Issue 11, p3109-3115. 7p. - Publication Year :
- 2019
-
Abstract
- A multicomponent two-step strategy for the synthesis of polysubstituted pyrrolo[3,2-c]pyridin-4-one derivatives has been described. The reactions can be readily performed by mixing inexpensive starting materials using two-step methods under mild conditions, and the products can be easily obtained from the mother liquid without any further treatment. Moreover, the solid acid catalyst can be circulated at least 6 times without obvious deactivation. Furthermore, a mechanism for the reaction process has been proposed. Overall the bond forming efficiency, the use of green solvent as the reaction medium, recyclability of the solid acid catalyst, easy work-up/purification, and a wide substrate scope make this method highly attractive to assemble heterocyclic scaffolds. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ACID catalysts
CATALYSTS recycling
Subjects
Details
- Language :
- English
- ISSN :
- 14639262
- Volume :
- 21
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- Green Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 136816680
- Full Text :
- https://doi.org/10.1039/c9gc01120j