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Anticancer saponin OSW-1 is a novel class of selective Golgi stress inducer.
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Jul2019, Vol. 29 Issue 14, p1732-1736. 5p. - Publication Year :
- 2019
-
Abstract
- OSW-1 is a plant-derived natural product proposed to selectively kill cancer cells by binding to members of the oxysterol binding protein family, thereby disrupting lipid/sterol homeostasis. However, how these protein-ligand interactions mediate cell death signaling has remained elusive. Here, we discovered that OSW-1 selectively activates the Golgi stress response leading to apoptosis, providing a mechanistic basis for the anticancer activity of OSW-1. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 29
- Issue :
- 14
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 136824802
- Full Text :
- https://doi.org/10.1016/j.bmcl.2019.05.022