Back to Search
Start Over
Synthesis and structure activity relationships of a series of 4-amino-1H-pyrazoles as covalent inhibitors of CDK14.
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Aug2019, Vol. 29 Issue 15, p1985-1993. 9p. - Publication Year :
- 2019
-
Abstract
- The TAIRE family of kinases are an understudied branch of the CDK kinase family, that have been implicated in a number of cancers. This manuscript describes the design, synthesis and SAR of covalent CDK14 inhibitors, culminating in identification of FMF-04-159-2, a potent, covalent CDK14 inhibitor with a TAIRE kinase biased selectivity profile. [ABSTRACT FROM AUTHOR]
- Subjects :
- *STRUCTURE-activity relationships
*KINASE inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 29
- Issue :
- 15
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 137030473
- Full Text :
- https://doi.org/10.1016/j.bmcl.2019.05.024