Back to Search
Start Over
Aβ production as consequence of cellular death of a human neuroblastoma overexpressing APP
- Source :
-
FEBS Letters . Jul2004, Vol. 570 Issue 1-3, p114-118. 5p. - Publication Year :
- 2004
-
Abstract
- In human brain the Aβ peptide is produced mainly by neurons and the overexpression of amyloid precursor protein (APP) that involves an increase in Aβ secretion, has been observed in some areas of the Alzheimer''s disease patients brain. We have generated two stably transfected human neuroblastoma lines which overexpress APP; both of them secreted Aβ and showed morphological changes and cell death with apoptotic program characteristics. Interestingly, coculture experiments with the untransfected human neuroblastoma cell line showed that the Aβ peptide was not responsible for the death in those cell lines; additionally, we indicate that upon cell death, Aβ peptide is secreted into cell medium. [Copyright &y& Elsevier]
- Subjects :
- *CELL death
*BRAIN
*ALZHEIMER'S disease
*PRESENILE dementia
Subjects
Details
- Language :
- English
- ISSN :
- 00145793
- Volume :
- 570
- Issue :
- 1-3
- Database :
- Academic Search Index
- Journal :
- FEBS Letters
- Publication Type :
- Academic Journal
- Accession number :
- 13704196
- Full Text :
- https://doi.org/10.1016/j.febslet.2004.06.025