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Antiprothombin antibodies and the diagnosis of antiphospholipid syndrome
- Source :
-
Clinical Immunology . Aug2004, Vol. 112 Issue 2, p144-149. 6p. - Publication Year :
- 2004
-
Abstract
- The preliminary classification criteria for definite antiphospholipid syndrome (APS) include the presence of anticardiolipin antibodies (aCL) and/or lupus anticoagulant (LA) as laboratory criteria. However, antiphospholipid antibodies (aPL) are a heterogeneous group of antibodies comprising also antibodies against phospholipid-binding proteins or their complexes with phospholipids. Prothrombin is one of the antigen recognized by aPL. In the last decade, there has been increasing interest in antibodies against prothrombin alone and those against phosphatidylserine–prothrombin complex. The latter, phosphatidylserine-dependent antiprothrombin antibodies (aPT), have been closely associated with APS and LA. In this paper, we review the properties of antiprothrombin antibodies. [Copyright &y& Elsevier]
- Subjects :
- *ANTIPHOSPHOLIPID syndrome
*AUTOIMMUNE diseases
*IMMUNOGLOBULINS
*GLOBULINS
Subjects
Details
- Language :
- English
- ISSN :
- 15216616
- Volume :
- 112
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Clinical Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 13705106
- Full Text :
- https://doi.org/10.1016/j.clim.2004.02.013