Back to Search
Start Over
Evaluation of the Effects of Clobazam on Seizure Control and Quality of Life in Children With Lennox-Gastaut Syndrome: A Pilot Study.
- Source :
-
Journal of Child Neurology . Jul2019, Vol. 34 Issue 8, p432-439. 8p. - Publication Year :
- 2019
-
Abstract
- Purpose: This is a prospective study of children with Lennox-Gastaut syndrome receiving clobazam as adjunctive therapy. This pilot study aims to examine medication effectiveness as it relates to seizure reduction, as well as improvement in parent-reported behavior and quality of life (QOL). Methods: Ten patients with Lennox-Gastaut syndrome aged 3-11 years were enrolled in this 6-week, 4 phase study. Seizure frequency, QOL, and Aberrant Behavior Checklist questionnaires were evaluated at 0, 2, 6, and 10 weeks during the study. Results: Patients showed improvement on indices of QOL, including physical activities (62.5%), well-being (37.5%), cognition (87.5%), social activities (37.5%), behavior (87.5%), general health (50%), and overall QOL (87.5%). The Quality of Life in Childhood Epilepsy (QOLCE) questionnaire revealed significant improvement in cognition (P =.008), social activities (P =.049), behavior (P =.038), and overall QOL (P =.018). The Aberrant Behavior Checklist exhibited a trend toward improvement in hyperactivity. Conclusion: There was improvement in all patients with documented baseline seizures (8/10), with 5 showing significant improvement (95%-100% reduction) and 3 showing minor improvement (7%-23% reduction). Statistically significant improvement in areas of cognition, social activities, behavior, and overall QOL were seen. An overall trend toward a positive well-being was seen in our patients with clobazam, as adjunct therapy for Lennox-Gastaut syndrome in children. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 08830738
- Volume :
- 34
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Journal of Child Neurology
- Publication Type :
- Academic Journal
- Accession number :
- 137058281
- Full Text :
- https://doi.org/10.1177/0883073819836534