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Resurgent Na+ Current Offers Noise Modulation in Bursting Neurons.

Authors :
Venugopal, Sharmila
Seki, Soju
Terman, David H.
Pantazis, Antonios
Olcese, Riccardo
Wiedau-Pazos, Martina
Chandler, Scott H.
Source :
PLoS Computational Biology. 6/21/2019, Vol. 15 Issue 6, p1-27. 27p. 9 Graphs.
Publication Year :
2019

Abstract

Neurons utilize bursts of action potentials as an efficient and reliable way to encode information. It is likely that the intrinsic membrane properties of neurons involved in burst generation may also participate in preserving its temporal features. Here we examined the contribution of the persistent and resurgent components of voltage-gated Na+ currents in modulating the burst discharge in sensory neurons. Using mathematical modeling, theory and dynamic-clamp electrophysiology, we show that, distinct from the persistent Na+ component which is important for membrane resonance and burst generation, the resurgent Na+ can help stabilize burst timing features including the duration and intervals. Moreover, such a physiological role for the resurgent Na+ offered noise tolerance and preserved the regularity of burst patterns. Model analysis further predicted a negative feedback loop between the persistent and resurgent gating variables which mediate such gain in burst stability. These results highlight a novel role for the voltage-gated resurgent Na+ component in moderating the entropy of burst-encoded neural information. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
1553734X
Volume :
15
Issue :
6
Database :
Academic Search Index
Journal :
PLoS Computational Biology
Publication Type :
Academic Journal
Accession number :
137123577
Full Text :
https://doi.org/10.1371/journal.pcbi.1007154