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A rhodium(iii)-catalyzed tunable coupling reaction of indole derivatives with alkylidenecyclopropanes via C–H activation.
- Source :
-
Chemical Communications . 7/4/2019, Vol. 55 Issue 52, p7558-7561. 4p. - Publication Year :
- 2019
-
Abstract
- We herein report a rhodium(iii)-catalyzed cross coupling of indole derivatives with alkylidenecyclopropanes (ACPs) in the presence of KCl, affording the alkene products exclusively with E-selectivity via C–H bond activation. The beta-H elimination to afford the conjugated diene derivatives has been suppressed by the addition of KCl. A plausible reaction mechanism has been proposed along with derivatization of the obtained product to demonstrate the practical usefulness of this synthetic protocol. [ABSTRACT FROM AUTHOR]
- Subjects :
- *INDOLE derivatives
*RHODIUM
*RHODIUM compounds
*DERIVATIZATION
Subjects
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 55
- Issue :
- 52
- Database :
- Academic Search Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 137151719
- Full Text :
- https://doi.org/10.1039/c9cc03134k