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Effect of Taoren-Quyu decoction on endometriosis in rats.
- Source :
-
Tropical Journal of Pharmaceutical Research . May2019, Vol. 18 Issue 5, p1057-1060. 4p. - Publication Year :
- 2019
-
Abstract
- Purpose: To study the effect of traditional Chinese Medicine formula Taoren-Quyu decoction (TQD) on endometriosis. Method: Fifty female Wistar rats were randomly separated into five groups (10 rats/group): normal control, model (untreated) group, positive control (danazol), 200 mg/kg/day (low dose) or 400 mg/kg/day (high dose). All rats were prepared into endometriosis except for normal control rats. TDQ groups rats were orally administered of TQD for 5 weeks. After treatment, the rats were sacrificed by cervical dislocation. The number of total endometriotic lesions were counted. Serum levels of cancer antigen 125 (CA-125), interleukin 13 (IL-13), interleukin 18 (IL-18) and peritoneal fluid tumor necrosis factoralpha (TNF-a) were measured by ELISA kits. Result: Compared with control rats, TQD reduced the number of total endometriotic lesions significantly (12.7 ± 1.2, p < 0.01), as well as serum levels of CA-125 (6.4 ± 1.2 U/mL), IL-18 (118.6 ± 7.4 pg/mL), IL- 13 (6.3 ± 0.8 pg/mL) and peritoneal fluid TNF-a (231.5 ± 11.7 pg/mL) (p < 0.01). Conclusion: The results reveal that TQD exerts anti-endometriotic effect in rats by inhibiting inflammatory factors. Therefore, TQD has potentials for use in the treatment of endometriosis. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CHINESE medicine
*ASCITIC fluids
*RATS
*FALLOPIAN tubes
*RAT control
Subjects
Details
- Language :
- English
- ISSN :
- 15965996
- Volume :
- 18
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Tropical Journal of Pharmaceutical Research
- Publication Type :
- Academic Journal
- Accession number :
- 137194435
- Full Text :
- https://doi.org/10.4314/tjpr.v18i5.20