NOP56在乳腺癌组织中的表达情况及对临床预后的意义.

NOP56 is a nucleolar protein that closely relates to the expression oncogene. In this paper， the differential expression gene analysis of the data from online database revealed that NOP56 is overexpressed in breast cancer tissues. The expression of NOP56 was used as a phenotype to analyze the difference between different phenotypes and clinical prognosis. Results showed that the high expression of NOP56 was closely related to the poor clinical pathological parameters and prognosis of breast cancer. The protein interaction network of NOP56 was obtained by differential gene enrichment analysis，and the semantic similarity of co-expressed genes was calculated. Finally，the clinically targeted drug actinomycin D (dactinomycin) of NOP56 and its co-expressed genes were obtained from an online database. These results provide potential new predictive indicators for breast cancer prevention and treatment， improve the molecular mechanism of clinical targeted drug use， and provide evidence and clues for the clinical use of targeted drugs. [ABSTRACT FROM AUTHOR]