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The Utility of Phosphohistone H3 (PHH3) in Follicular Lymphoma Grading: A Comparative Study With Ki-67 and H&E Mitotic Count.
- Source :
-
American Journal of Clinical Pathology . Jun2019, Vol. 151 Issue 6, p542-550. 9p. 3 Color Photographs, 1 Chart, 2 Graphs, 1 Map. - Publication Year :
- 2019
-
Abstract
- <bold>Objectives: </bold>To determine the utility of phosphohistone H3 (PHH3) mitotic count (MC) in grading follicular lymphoma (FL).<bold>Methods: </bold>FL cases were identified (2005-2017). Three hematopathologists recorded their average Ki-67 proliferation index, MC/high-power field (hpf) using PHH3 and H&E stains, and number of centroblasts/hpf. Results were assessed for correlations and interobserver variability.<bold>Results: </bold>Forty-three cases of FL were studied. PHH3 MC resulted in the strongest correlation to grade (r = 0.701, P < .0001) compared with Ki-67 proliferation index (PI) (r = 0.681, P < .0001) and H&E MC (r = 0.536, P = .0002) and the strongest linear relationship to centroblast count (R2 = 0.453). Agreement among pathologists was strongest for PHH3 (intraclass correlation coefficient [ICC] = 0.86) followed by Ki-67 PI (ICC = 0.85) and H&E MC (ICC = 0.78).<bold>Conclusions: </bold>PHH3 correlates best to histologic grade and has less interobserver variability compared with Ki-67 PI and H&E MC. These results support using PHH3 as an adjunct in FL grading. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00029173
- Volume :
- 151
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- American Journal of Clinical Pathology
- Publication Type :
- Academic Journal
- Accession number :
- 137290962
- Full Text :
- https://doi.org/10.1093/ajcp/aqz003