Back to Search
Start Over
Palladium/Norbornene-Catalyzed ortho Aliphatic Acylation with Mixed Anhydride: Selectivity and Reactivity.
- Source :
-
Organic Letters . 1/19/2018, Vol. 20 Issue 2, p325-328. 4p. - Publication Year :
- 2018
-
Abstract
- A palladium/norbornene-catalyzed ortho acylation for the efficient synthesis of functionalized alkyl aryl ketones is reported. Studies on the electronic and steric properties of mixed aryl anhydrides indicated that the cross-coupling favored with the electron-enriched aryl acyl group. DFT calculation on the oxidative addition of Pd(II) with 2,4,6-(Cl)3C6H2CO2C(O)Ph suggested that 2,4,6-(Cl)3C6H2C(O)-O bond cleavage was more kinetically disfavored than that of the PhC(O)-O bond by 11.7 kJ/mol. [ABSTRACT FROM AUTHOR]
- Subjects :
- *PALLADIUM
*ACYLATION
*ANHYDRIDES
*ACYL group
*DENSITY functional theory
Subjects
Details
- Language :
- English
- ISSN :
- 15237060
- Volume :
- 20
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Organic Letters
- Publication Type :
- Academic Journal
- Accession number :
- 137315108
- Full Text :
- https://doi.org/10.1021/acs.orglett.7b03514