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Characterization and differentiation of CD51+ Stem Leydig cells in adult mouse testes.
- Source :
-
Molecular & Cellular Endocrinology . Aug2019, Vol. 493, p110449-110449. 1p. - Publication Year :
- 2019
-
Abstract
- It was reported previously that adult mouse stem Leydig cells (SLCs) express CD51 (integrin α-chain V). However, it is still unclear whether all CD51+ cells are SLCs. In the present study, we found that CD51+ cells can be classified into two sub-groups, a weakly-staining group (CD51+) and a strongly-staining group (CD51++). The CD51+ cells expressed common SLC marker genes, including Nestin, Pdgfra and Coup-tf2, while CD51++ cells did not express these genes. Instead, they expressed macrophage markers, such as F4/80, Cd115 and Tnfa. When these cells were induced to differentiate in vitro, the CD51+ cells, but not CD51++ cells, formed Leydig cells. Overall, our results showed that although SLCs expressed CD51, not all CD51-expressing cells are SLCs. The cells that expressed high levels of CD51 are actually macrophages. • CD51+ cells of adult mouse testes contain two sub-populations. • The weakly-positive CD51 expressing cells in adult mouse testes are stem Leydig cells. • The strongly-positive CD51 cells in adult mouse testes are macrophages. [ABSTRACT FROM AUTHOR]
- Subjects :
- *LEYDIG cells
*STEM cells
*TESTIS
*SPERMATOGENESIS
*MICE
Subjects
Details
- Language :
- English
- ISSN :
- 03037207
- Volume :
- 493
- Database :
- Academic Search Index
- Journal :
- Molecular & Cellular Endocrinology
- Publication Type :
- Academic Journal
- Accession number :
- 137324218
- Full Text :
- https://doi.org/10.1016/j.mce.2019.110449