超早期立体定向手术治疗高血压脑出血的疗效及对患者炎性因子和生活质量的影响

Objective: To investigate the effect of ultra-early stereotactic surgery on hypertensive intracerebral hemorrhage(HICH)and its influence on inflammatory factors and quality of life. Methods: 93 patients with HICH who were admitted to our hospital from March 2016 to January 2018 were selected, and they were divided into early group(n=45, operation within 6-24 hours of onset) and super-early group(n=48, operation within 6 hours of onset) according to the timing of operation. Relevant indexes of curative effect,inflammatory factors and quality of life were compared between the two groups, and the occurrence of postoperative complications was observed. Results: The mortality of super-early group was lower than that of early group, and the Glasgow coma score(GOS) excellent and good rate was higher than that of early group(P <0.05). There was no significant difference in the postoperative rebleeding rate between the two groups(P>0.05). The levels of interleukin-6(IL-6), high-sensitivity C-reactive protein(hs-CRP) and tumor necrosis factor-α(TNF-α) were decreased in the two groups at 2 weeks after operation, and those in the ultra-early group were lower than those in the early group(P <0.05). The scores of mental health, physical health, social function and material life in the ultra-early group at 3 months and 6 months after operation were higher than those in the early group(P <0.05). The total incidence of postoperative complications in the ultra-early group was lower than that in the early group(P<0.05). Conclusion: Ultra-early stereotactic surgery for HICH has remarkable curative effect, which can effectively improve inflammatory factors and quality of life, and it can also reduce the incidence of postoperative complications. [ABSTRACT FROM AUTHOR]