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Fluorescence polarization-based detection of cancer-related mutations using target-initiated rolling circle amplification.
- Source :
-
Analyst . 7/21/2019, Vol. 144 Issue 14, p4149-4152. 4p. - Publication Year :
- 2019
-
Abstract
- We devised a new method to detect cancer-related mutations based on target-initiated rolling circle amplification in combination with fluorescence polarization. We then applied this method to identify the presence of KRAS G13D and G12D, two of the most frequent mutations found in colorectal cancer patients, demonstrating high sensitivity and specificity. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00032654
- Volume :
- 144
- Issue :
- 14
- Database :
- Academic Search Index
- Journal :
- Analyst
- Publication Type :
- Academic Journal
- Accession number :
- 137368408
- Full Text :
- https://doi.org/10.1039/c9an00429g