Reassessment of c-Kit+ Cells for Cardiomyocyte Contribution in Adult Heart.

Authors :: He, Lingjuan
Han, Maoying
Zhang, Zhenqian
Li, Yan
Huang, Xiuzhen
Liu, Xiuxiu
Pu, Wenjuan
Zhao, Huan
Wang, Qing-Dong
Nie, Yu
Zhou, Bin
Source :: Circulation. 7/9/2019, Vol. 140 Issue 2, p164-166. 3p.
Publication Year :: 2019
Abstract: The article presents a study on myogenic potential of Kit+ cardiac stem cells (CSCs) for cardiomyocyte contribution in adult heart. Topics discussed include reports of caveats proposed on Kit–Cre tools for the study of Kit+ CSCs, production of Kit–Cre drivers that label all Kit+ cells efficiently without removing the endogenous Kit gene, and examining the production of new cardiomyocytes remains by noncardiomyocytes that are labeled by new Kit–Cre tools and containing stem cells.