Back to Search Start Over

Recurrent Papillary Glioneuronal Tumor.

Authors :
Goethe, Eric A.
Youssef, Michael
Patel, Akash J.
Jalali, Ali
Goodman, J. Clay
Mandel, Jacob J.
Source :
World Neurosurgery. Aug2019, Vol. 128, p127-130. 4p.
Publication Year :
2019

Abstract

Papillary glioneuronal tumors (PGNTs) are rare World Health Organization grade I neoplasms that are characterized by a benign course and excellent response to surgical resection. A few reports exist of tumors with more aggressive clinical and histologic features. In this report we detail the case of an unusually aggressive PGNT in a 67-year-old woman. The patient had a 3-year history of seizures and was diagnosed with a frontoparietal mass on imaging. She underwent subtotal resection with a histologic diagnosis of PGNT. Less than a year after surgery, the patient experienced recurrence of disease and underwent reresection and adjuvant radiation treatment. The patient's disease continued to progress despite radiation treatment, so adjuvant temozolomide was initiated. Molecular testing was performed and revealed a TERT promotor mutation, an FGFR3-TACC3 oncogenic fusion, and a copy number loss in CDKN2A/CDKN2B. PGNTs, while typically benign, can rarely recur after surgery. Molecular testing should be performed on all PGNTs to help possibly identify more aggressive tumors and potentially reveal novel treatment options. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
18788750
Volume :
128
Database :
Academic Search Index
Journal :
World Neurosurgery
Publication Type :
Academic Journal
Accession number :
137560549
Full Text :
https://doi.org/10.1016/j.wneu.2019.04.266