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A Near-Infrared Triggered Intracellular pH Regulative PAMAM/O-nitrobenzaldehyde Coated UCNPs for Cancer Therapy.
- Source :
-
Integrated Ferroelectrics . 2019, Vol. 199 Issue 1, p85-94. 10p. - Publication Year :
- 2019
-
Abstract
- Dendrimers have become effective drug carriers and gene transfection vectors for medical biomaterials. In this experiment, UCNPs (NaGdF4:Tm, Yb@NaGdF4) and three-generation PAMAM dendrimers were prepared firstly; then NaGdF4:Tm, Yb@NaGdF4 was modified by Polyacrylic acid(PAA); PAMAM were grafted to the surface of the modified UCNPs by the reaction between amino groups and carboxyl groups; finally, O-nitrobenzaldehyde was grafted to the surface by Schiff base reaction.The synthesized upconversion materials were coated with PAA and PAMAM, then loaded with O-nitrobenzaldehyde to form spherical nanoparticles. The particle size of prepared nanoparticles is 75 ∼ 80 nm. The dendrimer complex can emit ultraviolet light to regulate the pH gradient of aqueous solution under the excitation of near-infrared light (980 nm), and can be used to kill cancer cells by changing the acidity of tissue cells; secondly, the cavity between dendrimers and dendrimers on the surface of the complex can be used in many fields such as drug delivery and gene transfection; the nanoparticles provide a new method for cancer treatment. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10584587
- Volume :
- 199
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Integrated Ferroelectrics
- Publication Type :
- Academic Journal
- Accession number :
- 137621771
- Full Text :
- https://doi.org/10.1080/10584587.2019.1592601