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Self-assembling of graphene oxide on carbon quantum dot loaded liposomes.
- Source :
-
Materials Science & Engineering: C . Oct2019, Vol. 103, p109860-109860. 1p. - Publication Year :
- 2019
-
Abstract
- This paper describes the design of stimuli-sensitive theranostic nanoparticles, composed of reduced graphene oxide (rGO) self-assembled on thermosensitive liposomes encapsulated doxorubicin (DOX) and carbon quantum dot (CQD) (CQD-DOX-rGO-Tlip). The rGO-Tlip particles have been observed to be flower-shaped objects. The thermoresponsive and theranostic potential of CQD-DOX-rGO-Tlips have been studied using differential scanning calorimetry (DSC), ultraviolet visible spectroscopy (UV–Vis), Raman spectroscopy and photoluminescent assays. The chemo-photothermal potential of rGO–Tlip on MD-MB-231 cells during NIR laser irradiation has been examined using MTT assay. Also, the ability of rGO–Tlip to be taken up by MD-MB-231 cells has been studied using confocal microscopy and flowcytometry. The results indicate that CQD-DOX-rGO-Tlips achieve a synergistic effect between photothermal therapy and chemotherapy for cancer treatment. Furthermore, online monitoring drug release is accomplished by studying the emission intensity of CQD while DOX released. • CQD-DOX-rGO-Tlips are introduced as a theranostic nanoparticles. • CQD-DOX-rGO-Tlips have a stimuli sensitive chemo-photothermal effect. • Online monitoring drug release can be achieved by using CQD-DOX-rGO-Tlips. • Flow cytometry confirm high cellular uptake of CQD-DOX-rGO-Tlips. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09284931
- Volume :
- 103
- Database :
- Academic Search Index
- Journal :
- Materials Science & Engineering: C
- Publication Type :
- Academic Journal
- Accession number :
- 137643553
- Full Text :
- https://doi.org/10.1016/j.msec.2019.109860