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Protective effects of a novel water-soluble biphenyl compound WLP-S-14 against acute-on-chronic liver failure in rats.
- Source :
-
Journal of Asian Natural Products Research . Sep2019, Vol. 21 Issue 9, p928-938. 11p. - Publication Year :
- 2019
-
Abstract
- This study investigated the therapeutic effects of a water-soluble biphenyl compound, WLP-S-14, in acute-on-chronic liver failure (ACLF). Wistar rats were injected intraperitoneally with porcine serum twice a week for 8 weeks prior to administration of 600 mg/kg D-galactosamine and 50 μg/kg lipopolysaccharide to induce ACLF. Study groups were treated intravenously with saline or with 100 or 200 mg/kg WLP-S-14. WLP-S-14 ameliorated ACLF with significant reductions in the mortality rate and transaminase levels, indicating improved liver function. The mechanism underlying these effects may involve decreased levels of tumor necrosis factor-α and interleukin-6, with associated inhibition of apoptotic pathways. [ABSTRACT FROM AUTHOR]
- Subjects :
- *AMINOTRANSFERASES
*ANIMAL experimentation
*APOPTOSIS
*BIOMARKERS
*BIOCHEMISTRY
*BIOLOGICAL models
*BIPHENYL compounds
*BLOOD coagulation
*CARBOHYDRATES
*HISTOLOGICAL techniques
*INTERLEUKINS
*LIVER
*LIVER failure
*MOLECULAR structure
*MORTALITY
*PHYSIOLOGIC salines
*RATS
*SERUM
*SURVIVAL
*TUMOR necrosis factors
*WESTERN immunoblotting
*LIPOPOLYSACCHARIDES
Subjects
Details
- Language :
- English
- ISSN :
- 10286020
- Volume :
- 21
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Journal of Asian Natural Products Research
- Publication Type :
- Academic Journal
- Accession number :
- 137680029
- Full Text :
- https://doi.org/10.1080/10286020.2019.1585822