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Current status and potential role of circular RNAs in neurological disorders.

Authors :
Lu, Shanshan
Yang, Xue
Wang, Chudong
Chen, Siqi
Lu, Shuang
Yan, Weitao
Xiong, Kun
Liu, Fengxia
Yan, Jie
Source :
Journal of Neurochemistry. Aug2019, Vol. 150 Issue 3, p237-248. 12p.
Publication Year :
2019

Abstract

Given the importance of non‐coding RNAs in modulating normal brain functions and their implications in the treatment of neurological disorders, non‐coding RNA‐based diagnostic and therapeutic strategies have shown great clinical potential. Circular RNAs (circRNAs) have emerged as potentially important players in this field. Recent studies have indicated that circRNAs might play vital roles in Alzheimer's disease, Parkinson's disease, ischemic brain injury, and neurotoxicity. However, the mechanisms of action of circRNAs have not been fully characterized. We aimed to review recent advances in circRNA research in the brain to provide new insights on the roles of circRNAs in neurological disorders. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00223042
Volume :
150
Issue :
3
Database :
Academic Search Index
Journal :
Journal of Neurochemistry
Publication Type :
Academic Journal
Accession number :
137720381
Full Text :
https://doi.org/10.1111/jnc.14724