F129EXOME SEQUENCING WITH SUBSEQUENT MULTI-TIER ANALYSES IN A LARGE COHORT OF MULTIPLY AFFECTED FAMILIES PROVIDES NEW INSIGHT INTO SCHIZOPHRENIA.

Highlights from the article: To prioritize the implicated genes for the follow-up analyses, large publicly available and inhouse WES datasets (> 3.000 SCZ patients) were analysed for additional pathogenic mutations in the newly identified candidate genes. In a subsequent multi-tier approach, we combined the WES data with gene expression data derived from brain tissues (both from publicly available datasets and our own inhouse SCZ brain samples), and complex protein-protein-interaction analyses. Additionally, the PPI analysis showed that both brain expressed genes, SMARCC1 and MECP2, were tightly connected with previously reported SCZ candidate genes.