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SA132THE RELATIONSHIP BETWEEN POLYGENIC RISK SCORES AND G IN PGC2 SCHIZOPHRENIA CASES.

Authors :
Richards, Alexander
Frizzati, Aura
Pardinas, Antonio
Tansey, Katherine
Donohoe, Gary
Corvin, Aiden
Ophoff, Roel
Rujescu, Dan
Sullivan, Patrick
Van Os, Jim
Andreassen, Ole
Strohmaier, Jana
Ripke, Stephan
O'Donovan, Michael
Walters, James
Source :
European Neuropsychopharmacology. 2019 Supplement4, Vol. 29, pS1261-S1261. 1p.
Publication Year :
2019

Abstract

Highlights from the article: B Background: b Cognitive impairment is a clinically important feature of schizophrenia but is not significantly impacted by current treatments. We were interested in establishing the relative contributions to variance in cognition in schizophrenia of schizophrenia risk alleles and alleles that influence cognitive ability in the general population. We examined the relationship between g and PRS for EA, population IQ, schizophrenia, bipolar disorder and major depressive disorder in 2825 schizophrenia case samples from the Psychiatric Genomics Consortium (PGC).

Details

Language :
English
ISSN :
0924977X
Volume :
29
Database :
Academic Search Index
Journal :
European Neuropsychopharmacology
Publication Type :
Academic Journal
Accession number :
137723885
Full Text :
https://doi.org/10.1016/j.euroneuro.2018.08.354