SU7ASSESSING THE CONTRIBUTION OF NEURODEVELOPMENTAL RISK ALLELES TO MATERNAL BEHAVIOURS AND LIFE-STYLE FACTORS.

Highlights from the article: B Background: b Exposures to adverse maternal behaviours and lifestyle factors prenatally have long been considered as potential risk factors for neurodevelopmental disorders and are biologically plausible because they impact during a sensitive time in development. B Methods: b Here, we test whether maternal polygenic risk scores for attention deficit/ hyperactivity disorder (ADHD), autism and schizophrenia are associated with maternal behaviours, lifestyle factors and health during pregnancy within the population-based cohort study ALSPAC. Our results also show no evidence of genetic confounding of other often reported risk factors like low birthweight and preterm delivery with neurodevelopmental disorders.