SU25USING POLYGENIC RISK SCORE APPROACHES TO INVESTIGATE THE COMMON-VARIANT GENETIC ARCHITECTURE OF COGNITION IN SCHIZOPHRENIA.

Highlights from the article: Identification of association-enriched gene-sets in each training set was derived from 134 central nervous system (CNS)-related gene-sets shown to capture the excess burden in schizophrenia for copy number variants [6]. The FMRP targets [1] gene-set preferentially captured variance in cognition in schizophrenia over other previously associated schizophrenia gene-sets when the GWAS of IQ was used to define risk alleles. One important observation was in marked contrast to genome wide polygenic risk score analyses, many gene-set polygenic risk scores capture maximal variance when risk alleles are defined at the genome wide significant threshold.