SU38EARLY ONSET DEPRESSION: CHARACTERISING DEVELOPMENTAL TRAJECTORIES AND THE ROLE OF NEUROPSYCHIATRIC GENETIC RISK VARIANTS.

Highlights from the article: Su38early onset depression: characterising developmental trajectories and the role of neuropsychiatric genetic risk variants B Results: b Latent class growth analysis identified three distinct trajectory classes - a persistently low class (73.7%), a late-adolescent-onset class (17.3%), and an early-adolescent-onset class (9.0%). The late-adolescent class, which had features of a "typical" post-pubertal-onset depression trajectory, was associated with an elevated genetic risk for depression as indexed by MDD PRS, but not with liability to neurodevelopmental disorders.