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Amiodarone hepatotoxicity. A clinicopathologic study of five patients.

Authors :
Rigas, B
Rosenfeld, L E
Barwick, K W
Enriquez, R
Helzberg, J
Batsford, W P
Josephson, M E
Riely, C A
Source :
Annals of Internal Medicine. Mar1986, Vol. 104 Issue 3, p348-351. 4p.
Publication Year :
1986

Abstract

Five patients had amiodarone hepatotoxicity detected on routine biochemical monitoring. Symptoms attributable to hepatotoxicity were minimal or absent; reversible hepatomegaly was seen in two patients, whereas three patients had signs of nonhepatic amiodarone toxicity before or with hepatotoxicity. Serum aminotransferase levels were elevated in all patients and alkaline phosphatase levels in four; no patient had hyperbilirubinemia or prolongation of the prothrombin time. Light microscopy showed steatosis, cellular degeneration, and cellular necrosis in the biopsy samples of four patients, whereas the fifth patient's sample had a granulomatous injury pattern. Electron microscopic study of liver tissue done in two patients showed phospholipid-laden lysosomal lamellar bodies. These findings suggest that both toxic and hypersensitivity liver injury can occur in response to amiodarone. The presence of phospholipid-laden lysosomal lamellar bodies may help differentiate amiodarone hepatotoxicity from alcoholic liver disease or other causes of hepatic steatosis. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00034819
Volume :
104
Issue :
3
Database :
Academic Search Index
Journal :
Annals of Internal Medicine
Publication Type :
Academic Journal
Accession number :
137746169
Full Text :
https://doi.org/10.7326/0003-4819-104-3-348