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Biomineralization synthesis of HBc-CuS nanoparticles for near-infrared light-guided photothermal therapy.
- Source :
-
Journal of Materials Science . Oct2019, Vol. 54 Issue 20, p13255-13264. 10p. 2 Diagrams, 5 Graphs. - Publication Year :
- 2019
-
Abstract
- Transition metal sulfide nanoparticles provide efficient tumor photothermal therapy under near-infrared light, while suffering from poor chemical stability and biocompatibility. Protein scaffolds are attractive templates to fabricate various inorganic nanostructures, due to their inherent capabilities of molecular recognition and self-assembly characteristics. Herein, a straightforward method is demonstrated for efficiently synthesizing CuS nanoparticles inside the inner cavity of the genetically modified hepatitis B core protein virus-like particles (HBc VLPs) via the affinity of histidine tags to copper ions. The monodispersed and well-defined HBc-CuS VLPs have been yielded with high efficiency and used as a potential photothermal agent for cancer therapy due to their excellent photothermal conversion efficiency, high cellular uptake and biocompatibility. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00222461
- Volume :
- 54
- Issue :
- 20
- Database :
- Academic Search Index
- Journal :
- Journal of Materials Science
- Publication Type :
- Academic Journal
- Accession number :
- 137770224
- Full Text :
- https://doi.org/10.1007/s10853-019-03613-6