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Quercetin‐3‐Oleate Contributes to Skin Wound Healing Targeting FFA1/GPR40.
- Source :
-
ChemistrySelect . 8/7/2019, Vol. 4 Issue 29, p8429-8433. 5p. - Publication Year :
- 2019
-
Abstract
- The hybrid molecule Quercetin‐3‐oleate (AV2), accommodates within the binding pocket for allosteric full GPR40 agonists. AV2 endorses skin wound healing acting as a promoter of keratinocytes proliferation and overcomes immunosuppressive conditions in vitro. AV2 stimulated HaCaT wound healing by 51% compared to the untreated control, at the concentration of 1 μM with slight TGF‐β production and MMP‐9 release. Pretreatment with the known GPR40 antagonist DC260126 abolished its wound healing power. Docking simulations suggested that both molecules share the same binding site. [ABSTRACT FROM AUTHOR]
- Subjects :
- *WOUND healing
*SKIN injuries
Subjects
Details
- Language :
- English
- ISSN :
- 23656549
- Volume :
- 4
- Issue :
- 29
- Database :
- Academic Search Index
- Journal :
- ChemistrySelect
- Publication Type :
- Academic Journal
- Accession number :
- 137943918
- Full Text :
- https://doi.org/10.1002/slct.201902572