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Fluorogenic 7-azidocoumarin and 3/4-azidophthalimide derivatives as indicators of reductase activity in microorganisms.
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Aug2019, Vol. 29 Issue 16, p2354-2357. 4p. - Publication Year :
- 2019
-
Abstract
- A series of fluorogenic heterocyclic azides were prepared and assessed as reductase substrates across a selection of Gram-negative and Gram-positive microorganisms. The majority of these azides showed similar activity profiles to nitroreductase substrates. Microorganisms that do not produce hydrogen sulfide reduced the azides, indicating reductase activity was not linked to hydrogen sulfide production. [ABSTRACT FROM AUTHOR]
- Subjects :
- *HYDROGEN sulfide
*MICROORGANISMS
Subjects
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 29
- Issue :
- 16
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 137972813
- Full Text :
- https://doi.org/10.1016/j.bmcl.2019.06.010