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Fluorogenic 7-azidocoumarin and 3/4-azidophthalimide derivatives as indicators of reductase activity in microorganisms.

Authors :
Chalansonnet, Valerie
Lowe, John
Orenga, Sylvain
Perry, John D.
Robinson, Shaun N.
Stanforth, Stephen P.
Sykes, Hannah E.
Truong, Thang V.
Source :
Bioorganic & Medicinal Chemistry Letters. Aug2019, Vol. 29 Issue 16, p2354-2357. 4p.
Publication Year :
2019

Abstract

A series of fluorogenic heterocyclic azides were prepared and assessed as reductase substrates across a selection of Gram-negative and Gram-positive microorganisms. The majority of these azides showed similar activity profiles to nitroreductase substrates. Microorganisms that do not produce hydrogen sulfide reduced the azides, indicating reductase activity was not linked to hydrogen sulfide production. [ABSTRACT FROM AUTHOR]

Subjects

Subjects :
*HYDROGEN sulfide
*MICROORGANISMS

Details

Language :
English
ISSN :
0960894X
Volume :
29
Issue :
16
Database :
Academic Search Index
Journal :
Bioorganic & Medicinal Chemistry Letters
Publication Type :
Academic Journal
Accession number :
137972813
Full Text :
https://doi.org/10.1016/j.bmcl.2019.06.010