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Effect of diet in females (F1) from prenatally undernourished mothers on metabolism and liver function in the F2 progeny is sex-specific.
- Source :
-
European Journal of Nutrition . Sep2019, Vol. 58 Issue 6, p2411-2423. 13p. 1 Diagram, 3 Charts, 5 Graphs. - Publication Year :
- 2019
-
Abstract
- Purpose: Poor maternal nutrition sensitises to the development of metabolic diseases and obesity in adulthood over several generations. The prevalence increases when offspring is fed with a high-fat (HF) diet after weaning. This study aims to determine whether such metabolic profiles can be transmitted to the second generation and even aggravated when the mothers were exposed to overnutrition, with attention to potential sex differences. Methods: Pregnant Wistar rats were subjected to ad libitum (control) or 70% food-restricted diet (FR) during gestation (F0). At weaning, F1 females were allocated to three food protocols: (1) standard diet prior to and throughout gestation and lactation, (2) HF diet prior to and standard diet throughout gestation and lactation, and (3) HF diet prior to and throughout gestation and lactation. F2 offspring was studied between 16 and 32 weeks of age. Results: FR-F2 offspring on standard diet showed normal adiposity and had no significant metabolic alterations in adulthood. Maternal HF diet resulted in sex-specific effects with metabolic disturbances more apparent in control offspring exposed to HF diet during gestation and lactation. Control offspring displayed glucose intolerance associated with insulin resistance in females. Female livers overexpressed lipogenesis genes and those of males the genes involved in lipid oxidation. Gene expression was significantly attenuated in the FR livers. Increased physical activity associated with elevated corticosterone levels was observed in FR females on standard diet and in all females from overnourished mothers. Conclusions: Maternal undernutrition during gestation (F0) improves the metabolic health of second-generation offspring with more beneficial effects in females. [ABSTRACT FROM AUTHOR]
- Subjects :
- *LIPID metabolism
*ADIPOSE tissues
*ADRENOCORTICAL hormones
*ANIMAL experimentation
*DIET in disease
*DIET therapy
*FAT content of food
*GENE expression
*GESTATIONAL age
*INSULIN resistance
*LACTATION
*LIVER
*LIVER function tests
*MALNUTRITION in pregnancy
*OXIDATION-reduction reaction
*RATS
*SEX distribution
*HYPERPHAGIA
*GLUCOSE intolerance
*PHYSICAL activity
*PRENATAL exposure delayed effects
Subjects
Details
- Language :
- English
- ISSN :
- 14366207
- Volume :
- 58
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- European Journal of Nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 138011368
- Full Text :
- https://doi.org/10.1007/s00394-018-1794-y