Diaminopyrimidine and diaminopyridine 5-HT7 ligands

Authors :: Denhart, Derek J.
Purandare, Ashok V.
Catt, John D.
Dalton King, H.
Gao, Aiming
Deskus, Jeffrey A.
Poss, Michael A.
Stark, Arlene D.
Torrente, John R.
Johnson, Graham
Mattson, Ronald J.
Source :: Bioorganic & Medicinal Chemistry Letters. Aug2004, Vol. 14 Issue 16, p4249-4252. 4p.
Publication Year :: 2004
Abstract: The present studies have identified a series of diaminopyrimidines and diaminopyridines as novel 5-HT7 receptor ligands. Three regiosiomeric classes of pyrimidines and four regioisomeric classes of pyridines were synthesized and analyzed for binding to the 5-HT7 receptor. The 5-HT7 binding affinities of different regioisomers show clearly the structure–activity relationship with position of ring nitrogens. [Copyright &y& Elsevier]