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Decreased hypothalamic aromatization in female rats of true precocious puberty
- Source :
-
Neuroscience Letters . Aug2004, Vol. 366 Issue 1, p92-96. 5p. - Publication Year :
- 2004
-
Abstract
- The true precocious puberty animal model induced by the single dose of danazol was used for investigating the expressions of hypothalamic aromatase in the advanced onset of puberty in rats. The day of vaginal opening and first estrus showed significant advancement in the model rats compared with the normal and vehicle rats (P < 0.01, respectively). The hypothalamic gonadotropin-releasing hormone (GnRH) mRNA expression increased significantly in the model rats compared with that in the normal and vehicle ones (P < 0.01). The levels of aromatase mRNA and protein expressions detected by RT-PCR and Western blot both decreased in the model rats compared with those in the normal and vehicle groups (P < 0.05). The results suggested that the hypothalamic aromatization might diminish in the onset of true precocious puberty of female rats. [Copyright &y& Elsevier]
- Subjects :
- *HYPOTHALAMIC hormones
*RATS
*PRECOCIOUS puberty
*ENDOCRINE diseases
Subjects
Details
- Language :
- English
- ISSN :
- 03043940
- Volume :
- 366
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Neuroscience Letters
- Publication Type :
- Academic Journal
- Accession number :
- 13807168
- Full Text :
- https://doi.org/10.1016/j.neulet.2004.05.012