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Microbiota-Derived Short-Chain Fatty Acids Promote the Memory Potential of Antigen-Activated CD8+ T Cells.
- Source :
-
Immunity (10747613) . Aug2019, Vol. 51 Issue 2, p285-285. 1p. - Publication Year :
- 2019
-
Abstract
- Interactions with the microbiota influence many aspects of immunity, including immune cell development, differentiation, and function. Here, we examined the impact of the microbiota on CD8+ T cell memory. Antigen-activated CD8+ T cells transferred into germ-free mice failed to transition into long-lived memory cells and had transcriptional impairments in core genes associated with oxidative metabolism. The microbiota-derived short-chain fatty acid (SCFA) butyrate promoted cellular metabolism, enhanced memory potential of activated CD8+ T cells, and SCFAs were required for optimal recall responses upon antigen re-encounter. Mechanistic experiments revealed that butyrate uncoupled the tricarboxylic acid cycle from glycolytic input in CD8+ T cells, which allowed preferential fueling of oxidative phosphorylation through sustained glutamine utilization and fatty acid catabolism. Our findings reveal a role for the microbiota in promoting CD8+ T cell long-term survival as memory cells and suggest that microbial metabolites guide the metabolic rewiring of activated CD8+ T cells to enable this transition. • Activated CD8+ T cells fail to transition into memory cells in mice lacking microbiota • Memory CD8+ T cells lacking GPR41 and GPR43 mount impaired recall responses • Butyrate promotes memory potential of activated CD8+ T cells • Butyrate enhances metabolism and uncouples the Krebs cycle from glycolytic input Bachem et al. reveal a role for the microbiota in promoting CD8+ T cell long-term survival as memory cells. Their findings suggest that microbial metabolites guide the metabolic rewiring of activated CD8+ T cells that enables this transition. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10747613
- Volume :
- 51
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Immunity (10747613)
- Publication Type :
- Academic Journal
- Accession number :
- 138097573
- Full Text :
- https://doi.org/10.1016/j.immuni.2019.06.002