Role of UHRF1 in malignancy and its function as a therapeutic target for molecular docking towards the SRA domain.

• UHRF1 is upregulated in several cancers. • UHRF1 levels are associated with stage, size and grade of the tumor. • UHRF1 can be used as a druggable target. • Docking of Propranolol, Nocodazole, Thymoquinone, Emodin, Napthazarin to SRA domain. The figure describes the location of UHRF1 (Ubiquitin-like with containing PHD and RING Finger domains 1) gene, mRNA and protein synthesis in the tumor cell and its structural domains with a focus on the docking of Naphthazarin on the SRA domain of UHRF1, resulting in reduction of tumor size. [ABSTRACT FROM AUTHOR]