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HectH9 hijacks glucose metabolism to fuel tumor growth.
- Source :
-
Molecular & Cellular Oncology . 2019, Vol. 6 Issue 5, p1-2. 2p. - Publication Year :
- 2019
-
Abstract
- Our study uncovered that HectH9 drives glycolysis and tumor development by K63-linked ubiquitination of Hexokinase 2 (HK2). This mechanism is critical for HK2 localization to mitochondria for activating HK2's functions in glycolysis promotion and apoptosis inhibition, suggesting that targeting HectH9 is a new strategy to tackle metabolism-addicted tumors. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 23723556
- Volume :
- 6
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Molecular & Cellular Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 138105609
- Full Text :
- https://doi.org/10.1080/23723556.2019.1644599