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The stimulation of thrombosis by hypoxia.
- Source :
-
Thrombosis Research . Sep2019, Vol. 181, p77-83. 7p. - Publication Year :
- 2019
-
Abstract
- Thrombus formation is increased under conditions of hypoxia in animal models of thrombosis and in human populations, but current therapies for thrombosis do not directly target hypoxia-responsive signaling pathways. The vascular response to hypoxia is controlled primarily by the hypoxia-inducible transcription factors (HIFs), whose target genes include several factors that regulate thrombus formation. In this article, we review the HIF-dependent and HIF-independent signaling pathways that regulate thrombus formation under hypoxic conditions. A better understanding of hypoxia-induced thrombus formation could lead to the development of novel prophylactic therapies for thrombosis. • Hypoxia is a stimulus for thrombus formation. • Hypoxia-inducible factors control the vascular response to hypoxia. • Thrombus formation can be regulated via HIF-dependent or -independent pathways. [ABSTRACT FROM AUTHOR]
- Subjects :
- *HYPOXIA-inducible factors
*HYPOXEMIA
*THROMBOSIS
*POPULATION
*TRANSCRIPTION factors
Subjects
Details
- Language :
- English
- ISSN :
- 00493848
- Volume :
- 181
- Database :
- Academic Search Index
- Journal :
- Thrombosis Research
- Publication Type :
- Academic Journal
- Accession number :
- 138128860
- Full Text :
- https://doi.org/10.1016/j.thromres.2019.07.013